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Rabbit Anti-Amylin/PE Conjugated antibody (bs-0057R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0057R-PE
英文名稱 Rabbit Anti-Amylin/PE Conjugated antibody
中文名稱 PE標(biāo)記的糖尿病相關(guān)肽/胰島淀粉樣肽抗體
別    名 Islet amyloid polypeptide; IAPP; DAP; Diabetes associated peptide; IAP; Insulinoma amyloid peptide.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  糖尿病  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Dog, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 10kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Amylin (1-37aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta amyloid (Abeta) assosciated with Alzheimer's disease, can induce apoptotic cell death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Function:
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Subunit:
Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.

Subcellular Location:
Secreted.

Post-translational modifications:
Amyloid fibrils are degraded by IDE.

Similarity:
Belongs to the calcitonin family.

Database links:

Entrez Gene: 751513 Cat

Entrez Gene: 3375 Human

Entrez Gene: 15874 Mouse

Entrez Gene: 100009489 Rabbit

Entrez Gene: 24476 Rat

Omim: 147940 Human

SwissProt: P12967 Cat

SwissProt: P10997 Human

SwissProt: P12968 Mouse

SwissProt: Q07334 Rabbit

SwissProt: P12969 Rat

Unigene: 46835 Human

Unigene: 415 Mouse

Unigene: 11394 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰島淀粉樣肽(islet amyloid polypeptide,IAPP)又稱amylin 或糖尿病相關(guān)肽是由胰腺β細(xì)胞產(chǎn)生的含37個(gè)氨基酸的一種短肽。IAPP降低胰島素的敏感性,抑制肌肉組織中葡萄糖的攝取和糖原的合成,抑制病人攝取食物。
據(jù)報(bào)道胰腺癌病人血漿IAPP濃度顯著升高,而在胃癌、結(jié)腸癌、肝癌、肺癌中正常,在糖尿病人中正?;蛏缘?。由于血漿IAPP濃度上升是胰腺癌的一個(gè)早期特征,因而檢測(cè)IAPP或IAPP釋放因子對(duì)于胰腺癌的早期診斷是有價(jià)值的。但目前還不清楚IAPP釋放因子的生化特性。
胰島淀粉樣多肽又稱胰淀素 IAPP ,胰島淀粉樣多肽在胰島β細(xì)胞中合成。并在β細(xì)胞中分泌,在各種疾病因素的誘導(dǎo)和激發(fā)作用下,IAPP生成異常增加而代謝降低,從而使其在胰島中聚集沉淀。
過量沉積的IAPP使胰島β細(xì)胞膜和胰島β細(xì)胞的超微結(jié)構(gòu)破壞,從而抑制了胰島素的分泌和對(duì)糖代謝平衡的協(xié)調(diào)作用,同時(shí)也抑制了葡萄糖對(duì)胰島素分泌的刺激作用,從而導(dǎo)致了胰島素分泌的不足,糖代謝平衡失調(diào),引發(fā)了糖尿病,胰島淀粉多肽是引發(fā)糖尿病的根本原因。由此可見如果能消除過量的IAPP,胰島β細(xì)胞的功能就可以恢復(fù)正常,糖尿病就有可能治愈。


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