| 產(chǎn)品編號 | bs-3313R-PE-Cy5 |
| 英文名稱 | Rabbit Anti-Phospho-Nur77(Ser351)/PE-Cy5 Conjugated antibody |
| 中文名稱 | PE-Cy5標(biāo)記的磷酸化孤兒核受體蛋白Nur77抗體 |
| 別 名 | NR4A1(phospho S351); NUR77 (phospho S351); p-NUR77 (phospho S351); GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 腫瘤 心血管 細胞生物 免疫學(xué) 染色質(zhì)和核信號 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 糖尿病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Nur77 around the phosphorylation site of Ser351 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Subunit: Binds DNA as a monomer. Interacts with GADD45GIP1. Subcellular Location: Nucleus. Tissue Specificity: Fetal muscle and adult liver, brain and thyroid. Post-translational modifications: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 3164 Human Entrez Gene: 15370 Mouse Omim: 139139 Human SwissProt: P22736 Human SwissProt: P12813 Mouse Unigene: 524430 Human Unigene: 119 Mouse Unigene: 10000 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 孤兒核受體蛋白Nur77是早期反應(yīng)轉(zhuǎn)錄因子之一，多種刺激因子如缺氧可誘導(dǎo)其迅速表達，Nur77參與調(diào)控細胞增殖、存活、分化等過程。這類核受體是體內(nèi)廣泛分布的配體依賴性的轉(zhuǎn)錄因子，通過調(diào)控基因協(xié)調(diào)表達，在機體的生長發(fā)育、新陳代謝，細胞分化及體內(nèi)許多生長發(fā)育過程中發(fā)揮重要作用，其功能障礙將導(dǎo)致一系列疾病的發(fā)生，如；癌癥、糖尿病、肥胖、不孕不育等等。 |
