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Rabbit Anti-BCA2/ZNF364/PE-Cy3 Conjugated antibody (bs-6757R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6757R-PE-Cy3
英文名稱 Rabbit Anti-BCA2/ZNF364/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的乳腺癌相關基因2抗體(鋅指蛋白364)
別    名 BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞類型標志物  腫瘤細胞生物標志物  鋅指蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.

Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.

Subunit:
Interacts with RAB7A.

Subcellular Location:
Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity).

Tissue Specificity:
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.

Post-translational modifications:
RING-type zinc finger-dependent and E2-dependent autoubiquitination.

Similarity:
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 101060478 Human

Entrez Gene: 27246 Human

Entrez Gene: 67845 Mouse

Entrez Gene: 362002 Rat

SwissProt: Q9Y4L5 Human

SwissProt: Q9D0C1 Mouse

Unigene: 523550 Human

Unigene: 386792 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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