| 產(chǎn)品編號(hào) | bs-6637R-Gold |
| 英文名稱 | Rabbit Anti-TP53I8/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的腫瘤蛋白p53誘導(dǎo)蛋白8 |
| 別 名 | Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TP53I8/EI24 (256-300aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy. Subunit: Interacts with BCL2. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness. Similarity: Belongs to the EI24 family. Database links: Entrez Gene: 9538 Human Entrez Gene: 13663 Mouse Omim: 605170 Human SwissProt: O14681 Human SwissProt: Q61070 Mouse Unigene: 643514 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
