| 產(chǎn)品編號(hào) | BIO1008SM |
| 英文名稱 | Anti-EGFR & HER3 Reference Antibody (Izalontamab Biosimilar) |
| 別 名 | ERBB1 / EGFR / HER1 & ERBB3 / HER3; Izalontamab |
| 抗體來源 | |
| 克隆類型 | Monoclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 197.22kDa |
| 性 狀 | Lyophilized |
| 亞 型 | IgG-ScFv |
| 純化方法 | Protein A |
| 緩 沖 液 | 100 mM Pro-Ac 20mM Arg pH 5.0 |
| 保存條件 | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | |
| 產(chǎn)品圖片 |
Izalontamab bound to hu-HER3-FL-HEK293 cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Izalontamab bound to hu-HER3-FL-HEK293 cells, and the EC50 was 1.225 nM.
Izalontamab bound to EGFR-CHO-K cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Izalontamab bound to EGFR-CHO-K cells, and the EC50 was 0.937 nM.
Izalontamab bound to HER3 protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Izalontamab bound to huHER3-his, and the EC50 was 0.059 nM.
Izalontamab bound to EGFR protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Izalontamab bound to huEGFR-his, and the EC50 was 0.019 nM.
The purity of Anti-EGFR & HER3 Reference Antibody (Izalontamab) is 99.43%, determined by SEC-HPLC.
Anti-EGFR & HER3 Reference Antibody (Izalontamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
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