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Anti-BCMA & CD3 Reference Antibody (Elranatamab Biosimilar) (BIO0967SM)  
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產(chǎn)品編號 BIO0967SM
英文名稱 Anti-BCMA & CD3 Reference Antibody (Elranatamab Biosimilar)
別    名 TNFRSF17 / BCMA / CD269 & CD3; Elranatamab  
抗體來源
克隆類型 Monoclonal
交叉反應(yīng) Human
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 145.44kDa
性    狀 Lyophilized
亞    型 IgG-like
純化方法 Protein A
緩 沖 液 100 mM Pro-Ac 20mM Arg pH 5.0
保存條件 -80°C for 2 years under sterile conditions; -20°C for 1 year under sterile conditions;Avoid repeated freeze-thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹
產(chǎn)品圖片
Co-incubation of Elranatamab-Bcmm with Jurkat cells, then with the addition of huBCMA-HEK293 cells for 6 hours. Bright-Lite was used to detect the fluorescent signal.As shown in fig, Elranatamab-Bcmm was able to activate the NF-AT signaling pathway, and the EC50 was 0.081 nM.
Elranatamab-Bcmm bound to huCD3e-jurkat cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Elranatamab-Bcmm bound to huCD3e-jurkat cells, and the EC50 was 64.990 nM.
Elranatamab-Bcmm bound to huBCMA-HEK293 cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Elranatamab-Bcmm bound to huBCMA-HEK293 cells, and the EC50 was 1.263 nM.
Elranatamab-Bcmm bound to BCMA protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Elranatamab-Bcmm bound to huBCMA-ECD-His , and the EC50 was 0.055 nM.
The purity of Anti-BCMA & CD3 Reference Antibody (Elranatamab) is 99.34%, determined by SEC-HPLC.
Anti-BCMA & CD3 Reference Antibody (Elranatamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The detected molecular weight of Anti-BCMA & CD3 Reference Antibody (Elranatamab) is 145.21 kDa. The mass spectrum exhibits two peaks, suggesting the possible presence of a homodimer.
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