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LILRB1 Recombinant Rabbit mAb (bsm-60710R)  
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產(chǎn)品編號 bsm-60710R
英文名稱 LILRB1 Recombinant Rabbit mAb
中文名稱 細(xì)胞表面免疫球蛋白樣轉(zhuǎn)錄因子2重組兔單抗
別    名 LIRB1_HUMAN; Leukocyte immunoglobulin-like receptor subfamily B member 1; ILT2; LIR1; MIR7; LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2(ILT-2); Monocyte/macrophage immunoglobulin-like receptor 7(MIR-7); CD85j;  
研究領(lǐng)域 細(xì)胞表面分子  淋巴細(xì)胞  b-淋巴細(xì)胞  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 R8A2
交叉反應(yīng) Human (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-1000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 72 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LILRB1 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

SWISS:
Q8NHL6

Gene ID:
10859

Database links:


Entrez Gene: 10859 Human

SwissProt: Q8NHL6 Human




產(chǎn)品圖片
Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1:THP-1, 2: Ramos, 3: A431, 4: Mouse brain, 5: Rat brain Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 71 kDa Observed MW: 115, 19 kDa
Tissue: Human liver Section type: Formalin-fixed & Paraffin embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:500 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for bsm-60710R
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