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CD146 Mouse mAb (bsm-30106M)  
訂購熱線:400-901-9800
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25ul/980.00元
50ul/1880.00元
大包裝/詢價
產(chǎn)品編號 bsm-30106M
英文名稱 CD146 Mouse mAb
中文名稱 黑色素瘤細胞粘附分子CD146單克隆抗體
別    名 A32 antigen; MCAM; Melanoma adhesion molecule; Melanoma associated antigen A32; Melanoma cell adhesion molecule; MelCAM; MUC18; Sendo1; MUC18_HUMAN.  CD 146; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; S endo 1; S endo 1 endothelial associated antigen; Sendo 1 endothelial associated antigen; MUC 18; CD146 antigen; Melanoma associated antigen MUC18; Melanoma associated glycoprotein
研究領域 腫瘤  免疫學  細胞粘附分子  細胞表面分子  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 P1H12
交叉反應 (predicted: Human)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1μl/Tests
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 118 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 0.5mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD146 
亞    型 IgG
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 MCAM (MUC18 antigen, CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MCAM (Melanoma adhesion molecule) has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MCAM. The close structural relationship with N-CAM and related molecules suggests that MCAM may be also a developmentally regulated cell adhesion.

Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

SWISS:
P43121

Gene ID:
4162

Database links:

Entrez Gene: 4162 Human

Entrez Gene: 84004 Mouse

Entrez Gene: 78967 Rat

Omim: 155735 Human

SwissProt: P43121 Human

SwissProt: Q8R2Y2 Mouse

SwissProt: Q9EPF2 Rat

Unigene: 599039 Human

Unigene: 275003 Mouse

Unigene: 2694 Rat



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