| 產(chǎn)品編號(hào) | bs-12269R |
| 英文名稱 | HIRIP3 Rabbit pAb |
| 中文名稱 | HIRA相互作用蛋白3抗體 |
| 別 名 | HIRA-interacting protein 3; HIRIP3; HIRA interacting protein 3; HIRP3; HIRP3_HUMAN. |
| 研究領(lǐng)域 | 心血管 發(fā)育生物學(xué) 干細(xì)胞 激酶和磷酸酶 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 62 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HIRIP3: 401-556/556 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]. Function: HIRIP3 (HIRA-interacting protein 3) is a novel gene product that was identified from its HIRA-binding properties. In vitro, HIRIP3 directly interacts with HIRA but also with core histones H2B and H3, suggesting that a HIRA-HIRIP3-containing complex could function in some aspects of chromatin and histone metabolism. Subunit: Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart. Post-translational modifications: Phosphorylated by CK2. SWISS: Q9BW71 Gene ID: 8479 Database links: Entrez Gene: 8479 Human Omim: 603365 Human SwissProt: Q9BW71 Human Unigene: 567370 Human |
