| 產(chǎn)品編號 | bs-8513R |
| 英文名稱 | NIR1 Rabbit pAb |
| 中文名稱 | 膜相關(guān)磷脂轉(zhuǎn)運蛋白抗體 |
| 別 名 | membrane-associated 3; CORD5; Membrane associated phosphatidylinositol transfer protein 3; Membrane-associated phosphatidylinositol transfer protein 3; NIR 1; NIR-1; NIR1; Phosphatidylinositol transfer protein; Phosphatidylinositol transfer protein, membrane-associated 3; PITM3_HUMAN; PITPnm 3; PITPNM; PITPNM family member 3; Pitpnm3; PYK2 N terminal domain interacting receptor 1; PYK2 N-terminal domain-interacting receptor 1; RDGBA3; retinal degeneration B alpha 3. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 轉(zhuǎn)運蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 106 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NIR1/RDGBA3: 131-250/974 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. Involvement in disease: Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) . CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. Function: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. Subunit: Interacts with PTK2B via its C-terminus. Subcellular Location: Endomembrane system; Peripheral membrane protein Tissue Specificity: Detected in brain and spleen, and at low levels in ovary. DISEASE: Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Similarity: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. Contains 1 DDHD domain. SWISS: Q9BZ71 Gene ID: 83394 Database links: Entrez Gene: 83394 Human Entrez Gene: 327958 Mouse Omim: 608921 Human SwissProt: Q9BZ71 Human SwissProt: Q3UHE1 Mouse Unigene: 183983 Human Unigene: 351793 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human MDA-MB-231 cell lysates
Lane 2: Human MCF-7 cell lysates
Lane 3: Human HeLa cell lysates
Primary: Anti-NIR1 (bs-8513R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 106 kDa
Observed band size: 120 kDa
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