| 產(chǎn)品編號 | bs-6585R |
| 英文名稱 | Desmoglein 3 Rabbit pAb |
| 中文名稱 | 橋粒芯蛋白3抗體 |
| 別 名 | 130 kD pemphigus vulgaris antigen; Balding; CDHF 6; CDHF6; Desmoglein 3 precursor; Desmoglein3; DKFZp686P23184; DSG 3; DSG3; DSG-3; Pemphigus vulgaris antigen; PVA; DSG3_HUMAN. |
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Specific References (3) | bs-6585R has been referenced in 3 publications.
[IF=4.996] Oike, Asami. et al. Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells. SCI REP-UK. 2022 Dec;12(1):1-15 IF ; Mouse.
[IF=4.3] Sumitomo et al. Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection. (2018) Front.Cell.Infect.Microbiol. 8:10 IF(IHC-P) ; Mouse.
[IF=0.32] B?R, Ferda, et al. "New immunohistochemical markers in the differential diagnosis of nonsmall cell lung carcinoma." Turkish Journal of Medical Sciences (2016). IHC-P ; Human.
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| 研究領(lǐng)域 | 信號轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子 細(xì)胞骨架 細(xì)胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 105 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Desmoglein 3: 50-75/999 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Tissue Specificity: Epidermis, tongue, tonsil, esophagus and carcinomas. Similarity: Contains 4 cadherin domains. SWISS: P32926 Gene ID: 1830 Database links: Entrez Gene: 1830 Human Omim: 169615 Human SwissProt: P32926 Human Unigene: 1925 Human |
| 產(chǎn)品圖片 |
Tissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Desmoglein 3 Polyclonal Antibody, Unconjugated(bs-6585R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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