| 產(chǎn)品編號 | bs-6531R |
| 英文名稱 | SKALP Rabbit pAb |
| 中文名稱 | 彈性蛋白酶抑制劑抗體 |
| 別 名 | ELAF_HUMAN; Elafin; Elastase Specific Inhibitor; Elastase-specific inhibitor; ES 1; ESI; Peptidase inhibitor 3; PI 3; PI-3; PI3; Protease inhibitor 3 skin derived; Protease inhibitor WAP3; SKALP; Skin derived Anti leukoproteinase; Skin-derived antileukoproteinase; Trappin 2; WAP four disulfide core domain protein 14; WAP four-disulfide core domain protein 14; WFDC14. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)菌及病毒 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 13 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SKALP/Elafin: 61-117/117 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008] Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Subcellular Location: Secreted. Similarity: Contains 1 WAP domain. SWISS: P19957 Gene ID: 5266 Database links: Entrez Gene: 5266 Human Omim: 182257 Human SwissProt: P19957 Human Unigene: 112341 Human Elafin,又稱SKALP(Skin-derived antileucoproteinase)或彈性蛋白酶特異性抑制劑(Elastase-Specific Inhibitor,ESI),它是一種低分子量的彈性蛋白酶抑制劑。它屬于“trappin”蛋白家族Trappin-2,具有拮抗胰彈性蛋白酶、中性粒細(xì)胞彈性蛋白酶(NE)和蛋白酶3的作用。 |
