| 產(chǎn)品編號 | bs-2523R |
| 英文名稱 | Rabbit Anti-CD99 antibody |
| 中文名稱 | CD99抗體 |
| 別 名 | T-cell surface glycoprotein E; T cell surface glycoprotein E2 precursor; 12E7; Antigen identified by monoclonal 12E7 Y homolog; Antigen identified by monoclonal antibodies 12E7 F21 and O13; CD 99; CD99 antigen; CD99 molecule; CD99X; E2 antigen; Ewing Sarcoma; MIC 2; MIC 2X; MIC 2Y; MIC2; MIC2X; MIC2Y; Monoclonal antibody 12E7; MSK5X; Protein MIC2; Surface antigen MIC2. |
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Specific References (1) | bs-2523R has been referenced in 1 publications.
[IF=20.565] Aguayo-Mazzucato C et al. β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. (2017) Cell.Metab. 25:898-910.e5 IF ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞表面分子 糖蛋白 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 16kDa |
| 檢測分子量 | 32 |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CD99: 45-150/175 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Subunit: Homodimer. Interacts with PILRB. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Natural killer cells. Similarity: Belongs to the CD99 family. SWISS: Q8VCN6 Gene ID: 673094 Database links: Entrez Gene: 4267 Human Entrez Gene: 673094 Mouse Omim: 313470 Human SwissProt: P14209 Human SwissProt: Q8VCN6 Mouse Unigene: 653349 Human Unigene: 423040 Mouse CD99（P30/32MIC2）是一種跨膜蛋白，為MIC2基因產(chǎn)物。分布于淋巴細(xì)胞、胸腺皮質(zhì)細(xì)胞、卵巢的顆粒細(xì)胞、胰島細(xì)胞和睪丸支持細(xì)胞。 |
